摘要:ScienceLondon第三方抗体验证数据库,来自抗体用户的反馈报告,为你提供最真实,最可靠的抗体选择参考!真正避免抗体带来的实验可重复性问题!NANOG抗体验证-SL0039

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Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation.

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一抗名称: Monoclonal NANOG antibody (STJ31850)

供应商: St John's Laboratory Ltd

验证方式: Immunohistochemistry

稀释比例: 1:500

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