摘要:ScienceLondon第三方抗体验证数据库,来自抗体用户的反馈报告,为你提供最真实,最可靠的抗体选择参考!真正避免抗体带来的实验可重复性问题!NFκB抗体验证-SL0023

[vc_row row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern" css_animation=""][vc_column][vc_tabs style="horizontal"][vc_tab title="抗体验证报告" tab_id="f8eded8e-8315-105a62-2d06"][vc_column_text]PDF Embedder requires a url attribute[/vc_column_text][/vc_tab][vc_tab title="关于目标蛋白" tab_id="8e4750f2-086a-75a62-2d06"][vc_column_text]

NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells

[/vc_column_text][/vc_tab][/vc_tabs][/vc_column][/vc_row][vc_row row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern" css_animation=""][vc_column][vc_separator type="normal" up="20" down="50"][vc_column_text]

一抗名称: NFκB-p65 Polyclonal Antibody(STJ94468) 100?l

供应商: St John's Laboratory Ltd

稀释比例: 1:1000

验证方式: Western Blot.

验证结果: In HeLa cell line, there was a target band detected by STJ94468. NFκB-p65 Polyclonal Antibody. In A549 cell line, there were no target bands detected by STJ94468 NFκB-p65 Polyclonal Antibody.

产品信息:NFκB-p65 Antibody

[/vc_column_text][/vc_column][/vc_row][vc_row row_type="row" use_row_as_full_screen_section="no" type="grid" angled_section="no" text_align="left" background_image_as_pattern="without_pattern" css_animation=""][vc_column][vc_separator type="transparent" up="20" down="50"][button size="big_large" icon="" target="_self" hover_type="default" font_weight="900" text_align="center" text="查看更多抗体验证报告" link="www.london-science.com/validation"][vc_separator type="transparent" up="20" down="50"][/vc_column][/vc_row]