摘要:ScienceLondon第三方抗体验证数据库,来自抗体用户的反馈报告,为你提供最真实,最可靠的抗体选择参考!真正避免抗体带来的实验可重复性问题!Phospho-Akt (S473) 抗体验证,由St John's Laboratory Ltd提供数据支持。

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Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase. The activated form can suppress FoxO gene transcription and promote cell cycle progression. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly.

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一抗名称: Phospho-Akt (S473) Polyclonal antibody (STJ90166)

供应商: St John's Laboratory Ltd

稀释比例: 1:1000

验证方式: Western Blot

验证样本: Mouse liver/colon lysates

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