摘要:ScienceLondon第三方抗体验证数据库,来自抗体用户的反馈报告,为你提供最真实,最可靠的抗体选择参考!真正避免抗体带来的实验可重复性问题!Polyclonal Gli1 抗体验证-SL0042,由St John's Laboratory Ltd提供数据支持。

[vc_row row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern" css_animation=""][vc_column][vc_tabs style="horizontal"][vc_tab title="抗体验证报告" tab_id="f8eded8e-8315-101537-d95863fe-5a68"][vc_column_text]PDF Embedder requires a url attribute[/vc_column_text][/vc_tab][vc_tab title="关于目标蛋白" tab_id="8e4750f2-086a-71537-d95863fe-5a68"][vc_column_text]

he Gli proteins are the effectors of Hedgehog (Hh) signaling and have been shown to be involved in cell fate determination, proliferation and patterning in many cell types and most organs during embryo development. In the developing spinal cord the target genes of Gli proteins, that are themselves transcription factors, are arranged into a complex gene regulatory network that translates the extracellular concentration gradient of Sonic hedgehog into different cell fates along the dorsoventral axis.

The Gli transcription factors activate/inhibit transcription by binding to Gli responsive genes and by interacting with the transcription complex. The Gli transcription factors have DNA binding zinc finger domains which bind to consensus sequences on their target genes to initiate or suppress transcription. Yoon showed that mutating the Gli zinc finger domain inhibited the proteins effect proving its role as a transcription factor. Gli proteins have an 18-amino acid region highly similar to the α-helical herpes simplex viral protein 16 activation domain. This domain contains a consensus recognition element for the human TFIID TATA box-binding protein associated factor TAFII31.Other proteins such as Missing in Metastasis (MIM/BEG4) have been shown to potentiate the effects of the Gli transcription factors on target gene transcription. Gli and MIM have been shown to act synergistically to induce epidermal growth and MIM + Gli1 overexpressing grafts show similar growth patterns to Shh grafts.

[/vc_column_text][/vc_tab][/vc_tabs][/vc_column][/vc_row][vc_row row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern" css_animation=""][vc_column][vc_separator type="normal" up="20" down="50"][vc_column_text]

一抗名称: Gli1 Antibody (STJ110685)

供应商: St John's Laboratory Ltd

稀释比例: 1:200

验证方式: Immunohistochemistry

验证样本: Interganglionic region (MGE/LGE) E12.5 ventral telencephalon

[/vc_column_text][/vc_column][/vc_row][vc_row row_type="row" use_row_as_full_screen_section="no" type="grid" angled_section="no" text_align="left" background_image_as_pattern="without_pattern" css_animation=""][vc_column][vc_separator type="normal" up="20" down="50"][button size="big_large" icon="" target="_self" hover_type="default" font_weight="900" text_align="center" text="查看更多抗体验证报告" link="www.london-science.com/validation"][/vc_column][/vc_row][vc_row row_type="row" use_row_as_full_screen_section="no" type="full_width" angled_section="no" text_align="left" background_image_as_pattern="without_pattern" css_animation=""][vc_column][vc_separator type="normal" up="20" down="50"][/vc_column][/vc_row]